Article ID Journal Published Year Pages File Type
8475470 Journal of Molecular and Cellular Cardiology 2011 9 Pages PDF
Abstract
► We investigated the role of Jak2 in Ang II-mediated neointima formation. ► Mice lacking VSMC Jak2 are protected from Ang II-mediated neointima formation. ► Jak2 null VSMC are protected from injury-induced phenotypic switching. ► Jak2 induces neointima formation and phenotypic switching via increased Jak2/STAT5 phosphorylation.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
Preview
Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice
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