Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8476067 | Mechanisms of Development | 2014 | 9 Pages |
Abstract
Hedgehog (Hh) acts as a morphogen to activate the transcription of diverse target genes via its downstream effector Cubitus interruptus (Ci). Currently, it is less understood how Ci recruits co-factors to activate transcription. Here we report that hyperplastic discs (hyd), an E3 ubiquitin ligase, can differentially regulate the transcriptional outputs of Hh signaling. We show that loss of Hyd activity caused upregulation of some, but not all of Hh target genes. Importantly, Hyd does not affect the stability of Ci. Our data suggest that Hyd differentially restrains the transcriptional activity of Ci via selective association with respective promoters.
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Authors
Guolun Wang, Xiaofang Tang, Yujie Chen, Jun Cao, Qinzhu Huang, Xuemei Ling, Wenyan Ren, Songqing Liu, Yihui Wu, Lorraine Ray, Xinhua Lin,