| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8476379 | Molecular and Cellular Endocrinology | 2018 | 39 Pages |
Abstract
Interactions of GR, MYC and MAPK pathways, from analysis of time course of altered gene regulation in CEM cells. GC (triangle) enters cell and activates GR, which by up- or down-regulating many genes, causes lowered activity and or amounts of antiapoptotic ERK and JNK and enhanced activity of proapoptotic p38. In forward feedback, p38 phosphorylates a specific ser of GR, which further enhances GR activity. GR down-regulates Myc which reduces transcription of JNK and further affects MAPKs via downregulation of various (yellow) other Myc-dependent genes. All arrows indicate direct or indirect regulation. Large right-angle arrows, up or down regulation. .Red indicates increased activity/amount; green, decreased.142
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Authors
M.S. Webb, A.L. Miller, T.L. Howard, B.H. Johnson, S. Chumakov, Y. Fofanov, T. Nguyen-Vu, C.Y. Lin, E.B. Thompson,