| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8476434 | Molecular and Cellular Endocrinology | 2018 | 28 Pages |
Abstract
Genetic mutations involving oncogenes or tumor suppressor genes are relatively uncommon in human sporadic pituitary tumors. Instead, increasing evidence has highlighted frequent epigenetic alterations including DNA methylation, histone modifications, and enhanced miRNA expression. This review covers some of this evidence as it illuminates mechanisms of tumorigenesis and highlights therapeutic opportunities.
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Authors
Shereen Ezzat, Sonia Cheng, Sylvia L. Asa,