Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8476539 | Molecular and Cellular Endocrinology | 2018 | 29 Pages |
Abstract
Obesity and cachexia represent divergent states of nutritional and metabolic imbalance but both are intimately linked to cancer. There is an extensive overlap in their signalling pathways and molecular components involved such as fatty acids (FAs), which likely play a crucial role in cancer. Forkhead box (FOX) proteins are responsible of a wide range of transcriptional programmes during normal development, and the FOXO3-FOXM1 axis is associated with cancer initiation, progression and drug resistance. Free fatty acids (FFAs), FA synthesis and β-oxidation are associated with cancer development and progression. Meanwhile, insulin and some adipokines, that are up-regulated by FAs, are also involved in cancer development and poor prognosis. In this review, we discuss the role of FA metabolism in cancer and how FA metabolism integrates with the FOXO3-FOXM1 axis. These new insights may provide leads to better cancer diagnostics as well as strategies for tackling cancer development, progression and drug resistance.
Keywords
AMPKFOXFABPFOXM1CPT1FOXO3COAIGF-IPPARSFAMUFAERKLCFAFFAEPAPI3KAPNMAPKadiponectinAktEicosapentaenoic aciddocosahexaenoic acidFatty acidFree fatty acidsaturated fatty acidfatty acid synthasemonounsaturated fatty acidPolyunsaturated fatty acidPUFAFatty acidsLong-chain fatty acidsinterleukintriacylglycerolTAG یا triacylglycerols tumour necrosis factor alphaforkhead boxDHACancerendoplasmic reticuluminsulin-like growth factor 1TNF-αFasnphosphoinositide 3-kinaseLipid metabolismFatty acid-binding proteinprotein kinase Bmitogen-activated protein kinaseCarnitine palmitoyltransferase 1coenzyme Aextracellular signal-related kinaseperoxisome proliferator-activated receptor
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Authors
Paula Saavedra-GarcÃa, Katie Nichols, Zimam Mahmud, Lavender Yuen-Nam Fan, Eric W-F. Lam,