Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8476542 | Molecular and Cellular Endocrinology | 2018 | 12 Pages |
Abstract
The adipose tissue microenvironment plays a key role in tumour initiation and progression because it provides fatty acids and adipokines to tumour cells. The fatty acid-binding protein (FABP) family is a group of small proteins that act as intracellular fatty acid transporters. Adipose-derived FABPs include FABP4 and FABP5. Both have an important role in lipid-related metabolic processes and overexpressed in many cancers, such as breast, prostate, colorectal and ovarian. Moreover, their expression in peritumoural adipose tissue is deregulated, and their circulating levels are upregulated in some tumours. In this review, we discuss the role of the peritumoural adipose tissue and the related adipokines FABP4 and FABP5 in cancer initiation and progression and the possible pathways implicated in these processes.
Keywords
TNMPPARγBATCD36FABP4CK1Retinoid X receptorFOXO3PAI-1IL-8MMP9RBP4ADFFOXM1RXRMMP2FABP5IGFBP-2MMP1IL-11BMATTGF-βPeroxisome proliferator-activated receptor β/δECMFFATNBCIL-6CAACAFCSCSTAT3MAPK/ERKPI3K/AKTPPARβ/δROSSp-1Ucp1epithelial to mesenchymal transitioninterleukin-11Interleukin-8interleukin-6Adipose tissueWhite adipose tissuebrown adipose tissuebone marrow adipose tissueTAMtransforming growth factor-βtumour necrosis factor-αtumour-associated macrophagesEMTforkhead box O3forkhead box M1cluster of differentiation 36NSCLCTriple negative breast cancerNon-small cell lung cancercancer stem cellcytokeratin 1body mass indexBMIVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)TNF-αphosphatase and tensin homologCancer-associated fibroblastsExtracellular matrixMatrix metalloproteinase-9Matrix metalloproteinase-1Matrix metalloproteinase-2signal transducer and activator of transcription 3Lipid metabolismSpecificity protein 1Plasminogen activator inhibitor-1fatty acid binding protein 4uncoupling protein 1Insulin-like growth factor-binding protein 2Retinol binding protein 4WATPtenReactive oxygen speciesperoxisome proliferator-activated receptor γ
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Authors
S. Guaita-Esteruelas, J. Gumà , L. Masana, J. Borrà s,