Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8476802 | Molecular and Cellular Endocrinology | 2016 | 20 Pages |
Abstract
Women with PCOS and EC have an increased endometrial expression of genes (IGF1, IGFBP1 and PTEN) involved in the insulin signalling pathway compared with control women. This may explain the increased risk of EC in PCOS women. This study provides a strong basis for clinical trials aiming to prevent EC in women with PCOS by investigating drugs targeting the insulin signalling pathway. This panel of genes may also serve as clinically useful early biomarkers which predict which women with PCOS will go on to develop EC.
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Authors
Mohamad Nasir Shafiee, Claire Seedhouse, Nigel Mongan, Caroline Chapman, Suha Deen, Jafaru Abu, William Atiomo,