Article ID Journal Published Year Pages File Type
8476863 Molecular and Cellular Endocrinology 2016 10 Pages PDF
Abstract
Schematic model of AEA activity along the HPG axis. Injection of AEA in male frogs down-regulates the HPG axis targeting kisspeptin/Gnrh systems in the hypothalamus and up-regulates Cyp19 in testis. As a consequence, intratesticular testosterone levels are low whereas estrogen biosynthesis increases and negative feedback mechanisms occur in both hypothalamus and pituitary. In testis high estrogen levels induce Faah protein production; AEA increases Cyp19 expression and thus, via estradiol, modulates its tone.109
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