Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8476913 | Molecular and Cellular Endocrinology | 2015 | 13 Pages |
Abstract
New evidance highlights the importance of food timing. Recently, we showed that a low-calorie diet with carbohydrates eaten mostly at dinner changed diurnal hormone secretion and led to greater weight loss and improved metabolic status in obese people. Herein, we set out to test whether concentrated-carbohydrates diet (CCD), in which carbohydrates are fed only before sleep, leads to an improved metabolic status in mouse hypothalamus and peripheral tissues. Diet-induced obese mice were given concentrated or distributed carbohydrate diet for 6 weeks. Obese mice fed CCD ate 8.3% less, were 9.3% leaner and had 39.7% less fat mass. Leptin, ghrelin and adiponectin displayed altered secretion. In addition, these mice exhibited an improved biochemical and inflammatory status. In the hypothalamus, anorexigenic signals were up-regulated and orexigenic signals were down-regulated. In peripheral tissues, CCD promoted adiponectin signaling, repressed gluconeogenesis, enhanced lipid oxidation and lowered inflammation, thus ameliorating the major risk factors of obesity.
Keywords
ACCGlucose 6 phosphataseObRbHFHSG6PaseDCDUCP2PEPCKpro-opiomelanocortinMCHGHSRPGC-1αPOMCAgRPNPYiNOSAMPKTNFαIL-6CCDHOMA-IRALTperoxisome proliferator-activated receptor gamma coactivator 1-alphaAMP-activated protein kinasePPARsadiponectinASTAspartate aminotransferaseAlanine aminotransferasehomeostasis model assessment of insulin resistanceacetyl coA carboxylaseinterleukin 6tumor necrosis factor alphaFeeding behaviorZeitgeber timeinducible nitric oxide synthaseMetabolic syndromephosphoenolpyruvate carboxykinaseLeptinMelanin concentrating hormoneuncoupling protein 2Agouti-related proteinGhrelingrowth hormone secretagogue receptorPeroxisome proliferator-activated receptorsAdiponectin receptorsNeuropeptide Y
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Authors
Sigal Sofer, Abraham Eliraz, Zecharia Madar, Oren Froy,