| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8476973 | Molecular and Cellular Endocrinology | 2015 | 9 Pages |
Abstract
- HCO3â activates mitochondrial adenylyl cyclase (sAC) in human adrenocortical cells.
- Angiotensin II causes a mitochondrial [cAMP] rise in a [Ca2+]mito-dependent way.
- cAMP signal is reduced by siRNA for sAC, and enhanced by PDE2-inhibitor.
- Inhibition of sAC attenuates angiotensin II-induced aldosterone secretion.
Keywords
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Authors
Dávid Katona, Anikó Rajki, Giulietta Di Benedetto, Tullio Pozzan, András Spät,