| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8476975 | Molecular and Cellular Endocrinology | 2015 | 10 Pages |
Abstract
- We discover SIRT1 activating compounds originated from oriental medicinal plants.
- Dehydroabietic acid could be a novel anti-aging compound and provide scientific evidences of the anti-aging effects.
- Aging model organism, C.âelegans lifespan extension effect of dehydroabietic acid is due to direct binding and activating SIRT1.
- Dehydroabietic acid prevents age-related pigment, lipofuscin accumulation in human dermal fibroblast.
- We propose a direct binding model for dehydroabietic acid and SIRT1.
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Authors
Juewon Kim, Young-Gyu Kang, Jee-young Lee, Dong-hwa Choi, Young-uk Cho, Jae-Min Shin, Jun Seong Park, John Hwan Lee, Wan Gi Kim, Dae Bang Seo, Tae Ryong Lee, Yusei Miyamoto, Kyoung Tai No,