Article ID Journal Published Year Pages File Type
8476990 Molecular and Cellular Endocrinology 2015 11 Pages PDF
Abstract

- In vivo blockade of testicular α1-ADRs reduces circulating androgen level.
- α1-ADR blockade abolished stress-induced partial recovery of androgen production.
- α1-ADRs mediate stress-reduced steroidogenic stimulator Nur77 in Leydig cells.
- α1-ADRs mediate stress-increased repressors Dax1 and Arr19 in Leydig cells.
- α1-ADRs on Leydig cell regulate transcription of steroidogenic stimulator Nur77.
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