| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477001 | Molecular and Cellular Endocrinology | 2015 | 10 Pages |
Abstract
- MC4R mechanisms of action were studied.
- MC4R-induced BDNF expression involves ERK and cFos activation in astrocytes and rat hypothalamus.
- Inhibition of PI3K, Src and RSK blocked MC4R-induced BDNF expression in astrocytes.
Keywords
GPCRNDP-MSHRSKPDK1HprtMC4RcFosα-MSHCREBpKaDAPIERKRT-qPCRPI3KMCRHmbGFAPBDNFMAPKadenylate cyclaseAstrocytesBrain-derived neurotrophic factorphosphoinositide-3 kinaseα-melanocyte-stimulating hormoneHypothalamusHypoxanthine–guanine phosphoribosyltransferasecAMP responsive element binding proteinGlial fibrillary acidic proteinprotein kinase Amitogen activated protein kinaseextracellular signal-regulated kinasemelanocortin receptorG protein-coupled receptor
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Authors
D. RamÃrez, J. Saba, L. Carniglia, D. Durand, M. Lasaga, C. Caruso,