Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats

Article ID	Journal	Published Year	Pages	File Type
8477049	Molecular and Cellular Endocrinology	2015	12 Pages	PDF

Abstract

Decreased miR-144 could enhance TNF-Î± and IFN-Î³ production by targeting TLR2 in vitro, and might contribute to TLR2 up-regulation and the progression of NASH in HFD-MetS E3 rats. This might offer a novel and potential target for NASH therapy.

Keywords

HFD NAFLD miR-144 TBST BMM RT-qPCR BMC FBS DMEM nonalcoholic steatohepatitis Dulbecco's modification of Eagle's medium non-alcoholic fatty liver disease High fat diet real-time quantitative PCR fetal bovine serum Bone marrow cells Bone marrow-derived macrophages MicroRNA MiRNA Nash

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology

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Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats

Authors

Dongmin Li, Xuan Wang, Xi Lan, Yue Li, Li Liu, Jing Yi, Jing Li, Qingzhu Sun, Yili Wang, Hongmin Li, Nannan Zhong, Rikard Holmdahl, Shemin Lu,