| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477143 | Molecular and Cellular Endocrinology | 2015 | 11 Pages |
Abstract
- TGFβ isoforms and both TGFβ receptors are expressed in the developing hypothalamus.
- TGFβ2 regulates both TIEG1 and Trh expressions in a TβRI dependent manner.
- TIEG1 binds to a GC rich sequence on the promoter region to regulate Trh expression.
- TGFβ2, through TIEG1 action, regulates Trh expression within the hypothalamus.
- TIEG1 expression is necessary but not sufficient for the correct hypothalamic Trh expression.
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Authors
Miriam MartÃnez-Armenta, Sol DÃaz de León-Guerrero, Ana Catalán, Lourdes Alvarez-Arellano, Rosa Maria Uribe, Malayannan Subramaniam, Jean-Louis Charli, Leonor Pérez-MartÃnez,