| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477150 | Molecular and Cellular Endocrinology | 2014 | 24 Pages |
Abstract
The percentage of TSHR mutation positive HTNs in children and adolescents is within the range observed in adults. Contrary to adults, the M453T mutation is the predominant TSHR mutation in HTNs of children and adolescents. The increased malignancy rate of HTNs of children does not appear to be associated with RAS, BRAF, PAX8/PPARG and RET/PTC mutations.
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Authors
Markus Eszlinger, Marek Niedziela, Eva Typlt, Holger Jaeschke, Sandra Huth, Jörg Schaarschmidt, Thomas Aigner, Ewa Trejster, Knut Krohn, Eileen Bösenberg, Ralf Paschke,