| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477267 | Molecular and Cellular Endocrinology | 2013 | 11 Pages |
Abstract
Melatonin, an antioxidant, protects the human placental syncytiotrophoblast against hypoxia/reoxygenation-induced oxidative stress and the subsequent mitochondrial-mediated apoptosis damage. These highlight the potential preventive and therapeutic use of melatonin in pregnancy complications characterized by syncytiotrophoblast survival alteration.65
Keywords
STBMNF-κBROCK-1XDHpeptidylprolyl isomerase ACATHIF-1GPXHPRT1PPIAPARPsFlt-1Xanthine oxidaseH/RROSAntioxidantMitochondrial apoptosisVillous trophoblastsoluble fms-like tyrosine kinase 1tumor necrosis factor αXanthine dehydrogenasesuperoxide dismutase 1Superoxide dismutase 2hypoxia inducible factor 1TNF-αnuclear factor-κBreverse-transcriptionHypoxanthine phosphoribosyltransferase 1hypoxia/reoxygenationquantitative polymerase chain reactionPoly(ADP-ribose) polymeraseCatalaseglutathione peroxidaseReactive oxygen species
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Dave Lanoix, Andrée-Anne Lacasse, Russel J. Reiter, Cathy Vaillancourt,