Article ID Journal Published Year Pages File Type
8477397 Molecular and Cellular Endocrinology 2013 13 Pages PDF
Abstract

- Hypothyroidism inhibits glutamate uptake and increases Ca2+ influx in rat hippocampus.
- The glutamate-glutamine cycle is compromised by hypothyroid condition.
- Hypothyroidism leads to decreased neuronal and glial cell population in hippocampus.
- Oxidative stress is involved in neural cell damage caused by hypothyroidism.
- S100B could be a biomarker of brain damage in hypothyroidism during development.
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