cAMP/PKA signaling defects in tumors: Genetics and tissue-specific pluripotential cell-derived lesions in human and mouse

Article ID	Journal	Published Year	Pages	File Type
8477546	Molecular and Cellular Endocrinology	2013	13 Pages	PDF

Abstract

âº cAMP signaling may affect cell growth, development, and tumor formation in cAMP-sensitive tissues. âº Primary bilateral adrenal hyperplasias are genetically heterogeneous; most have defects in cAMP. âº Tissue-specific pluripotential cells may initiate tumor formation in cAMP-sensitive tissues.

Keywords

ACC PRKAR1A Adrenocortical hyperplasia NOMID PRKAR1A Gene cAMP signaling pathway ACT PDE ACA CREB Adrenal cortical adenoma primary pigmented nodular adrenocortical disease PPNAD Bah Tumor Adrenal glands Phosphodiesterase LOH Bilateral adrenal hyperplasia Adrenal cortical carcinoma