Characterization of the LPS-induced inflammation of the adrenal gland in mice

Article ID	Journal	Published Year	Pages	File Type
8477549	Molecular and Cellular Endocrinology	2013	8 Pages	PDF

Abstract

âº Systemic administration of LPS induces inflammation in the adrenal gland. âº LPS induces endothelial inflammation and dysfunction in the adrenal gland. âº LPS administration induces expression of various chemokines in the adrenal gland. âº Increased chemokines expression associates with leukocyte recruitment into adrenal. âº LPS-mediated adrenal gland inflammation associates with increased apoptosis rate.

Keywords

ACTH VCAM ICAM SIRS CCL CXCL TLR C5aR chemokine (C–X–C motif) ligand Interferone LPS mPGES Microsomal prostaglandin E synthase PGRP NOS chemokine (C–C motif) ligand MPO leukocyte recruitment Endotoxemia IFN interleukin TdT-mediated dUTP nick-end labeling TUNEL cluster of differentiation Systemic inflammatory response syndrome tumor necrosis factor TNF-α lipopolysaccharide Vasculature intracellular adhesion molecule vascular adhesion molecule myeloperoxidase HPA nitric oxide synthase adrenocorticotropic hormone hypothalamic–pituitary–adrenal Peptidoglycan recognition protein Chemokines Toll-like receptors