| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477570 | Molecular and Cellular Endocrinology | 2013 | 11 Pages |
Abstract
⺠GABAA receptor ε subunit (GABRE) is miR-224 host gene. ⺠TGF-β1 enhanced the binding of p53/p65 to the proximal promoter of GABRE in GCs. ⺠p53/p65 transcriptionally cooperated to inactivate the GABRE promoter in GCs. ⺠p53/p65 suppressed the TGF-β1-induced increase in pri-miR-224 expression in GCs. ⺠p53/p65 influenced GC proliferation and E2 release through miR-224-Smad4 pathway.
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Authors
Meng Liang, Guidong Yao, Mianmian Yin, Mingrong Lü, Hui Tian, Lin Liu, Jie Lian, Xingxu Huang, Fei Sun,