Article ID Journal Published Year Pages File Type
8477582 Molecular and Cellular Endocrinology 2013 9 Pages PDF
Abstract
► The Ca2+-activated K+-channel (BKCa) is expressed by Leydig cells in adult hamster and human testis. ► BKCa is activated upon LH-receptor activation. ► It is responsible for the hCG-induced hyperpolarization of the Leydig cell membrane. ► Inhibition of BKCa abolishes hyperpolarization but increases testosterone and StAR levels. ► Thus BKCa is involved in limiting the production of testosterone evoked by LH-receptor activation.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
Preview
The Ca2+-activated, large conductance K+-channel (BKCa) is a player in the LH/hCG signaling cascade in testicular Leydig cells
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