Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8477587 | Molecular and Cellular Endocrinology | 2013 | 10 Pages |
Abstract
⺠In early onset pre-eclampsia the placental LEP promoter is hypomethylated. ⺠Leptin is elevated in maternal plasma from these individuals. ⺠In the placenta, expression of LEP alleles appear to be randomly skewed. ⺠In early onset pre-eclampsia there is a tendency for biallelic LEP expression. ⺠This may be associated with loss of methylation and increased leptin expression.
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Authors
Kirsten Hogg, John D. Blair, Peter von Dadelszen, Wendy P. Robinson,