| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477592 | Molecular and Cellular Endocrinology | 2013 | 11 Pages |
Abstract
⺠We used an ovine prenatal exposure model to a mixture of environmental chemicals. ⺠Male fetal thyroids of mixed exposure groups have reduced follicle counts. ⺠Fetal thyroids of animals in mixed exposure groups show increased proliferation. ⺠Thyroid glands of exposed fetuses showed regions with impaired differentiation. ⺠Fetal plasma levels of free thyroid hormones were normal.
Keywords
transthyretinTTRTSHFT4DEHPhptHRPPCBsPBDEfT3GnRHDAB3,3′-diaminobenzidine tetrahydrochlorideECsEDCsNiSEndocrine disruptorsPolychlorinated biphenylsTerminal deoxynucleotidyl transferase dUTP nick end labelingEndocrine-disrupting compoundsTUNELFree thyroxinefetalRoom temperaturedi(2-ethylhexyl) phthalatePolybrominated diphenyl etherDevelopmentgestational daysodium-iodide symporterFree triiodothyronineCoefficient of VariationThyroid glandSewage sludgeHypothalamic-pituitary-thyroid axisEnvironmental chemicalshematoxylin-eosingonadotropin releasing hormoneThyroid hormonethyroid stimulating hormoneHorseradish peroxidaseSheepthyroid hormone receptor
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Authors
Sabine Hombach-Klonisch, Adrian Danescu, Farhana Begum, Maria R. Amezaga, Stewart M. Rhind, Richard M. Sharpe, Neil P. Evans, Michelle Bellingham, Corinne Cotinot, Beatrice Mandon-Pepin, Paul A. Fowler, Thomas Klonisch,