| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477605 | Molecular and Cellular Endocrinology | 2012 | 11 Pages |
Abstract
⺠The vitamin D hormone enhances CYP3A4 and CYP3A5 expression within prostate cells. ⺠Vitamin D regulation of CYP3A4 and CYP3A5 was directly mediated through VDR. ⺠Vitamin D treatment increased CYP3A enzyme activity with LNCaP cells. ⺠Elevated CYP3A function increased the intracellular inactivation of testosterone.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Orla Maguire, Catherine Pollock, Philip Martin, Andrew Owen, Thomas Smyth, Declan Doherty, Moray J. Campbell, Stephen McClean, Paul Thompson,