| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477610 | Molecular and Cellular Endocrinology | 2012 | 12 Pages |
Abstract
⺠The article presents molecular modeling of GTHs and GTHRs of tilapia, trout and eel. ⺠Each of the gonadotropins of eel, trout tilapia and human activated its own cognate receptors. ⺠Tilapia LHR was activated by hCG and eel LHR was activated by hFSH, hCG, and trout FSH. ⺠For FSHR, the only cross-reactivity detected was for hFSHR, which was activated by pFSH and bFSH.
Keywords
LRRFSHRLUCtPALHRECD12-O-tetradecanoylphorbol-13-acetateGTHTSHpKaTilapia (Oreochromis niloticus)GPCRG-protein-coupled receptorG-protein-coupled receptor (GPCR)Humanleucine-rich repeatextracellular domainluciferaseMolecular modelingSignal transductionThyroid-stimulating hormonefollicle-stimulating hormoneluteinizing hormoneFSHprotein kinase ABovinegonadotropinsPorcinechorionic gonadotropinFSH receptorLH receptorglycoprotein hormone receptorGonadotropin receptor
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Authors
Joseph Aizen, Noga Kowalsman, Makito Kobayashi, Lian Hollander, Young Chang Sohn, Goro Yoshizaki, Masha Y. Niv, Berta Levavi-Sivan,