| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477622 | Molecular and Cellular Endocrinology | 2012 | 7 Pages |
Abstract
⺠We stimulated the calcium sensing receptor (CaSR) in adipose cells and tissue with the calcimimetic cinacalcet. ⺠Cinacalcet elicited an elevation in the expression of inflammatory cytokines. ⺠NFκB inhibition partly reverted the observation suggesting it mediates the effect of CaSR stimulation. ⺠The CaSR could play a role in obesity-induced adipose tissue dysfunction.
Keywords
GAPDHIκBαCaSRHBSSIL6pTHCC chemokine ligand 2CCL2TNFαDMEM:F12cDNAHanks balanced salt solutionIL1βNFκBcomplementary deoxyribonucleic acidRNAribonucleic acidinflammationinterleukin 1 betainterleukin 6ELISAEnzyme-linked immunosorbent assaytumor necrosis factor alphaCytokinesnuclear factor kappa BObesityparathyroid hormoneCalcium sensing receptor
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Authors
Mariana Cifuentes, Cecilia Fuentes, Nicolas Tobar, Ingrid Acevedo, Elisa Villalobos, Eric Hugo, Nira Ben-Jonathan, Marcela Reyes,