| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477626 | Molecular and Cellular Endocrinology | 2012 | 11 Pages |
Abstract
⺠MC5R internalizes independently of β-arrestins and recycles to cell surface. ⺠α-MSH binding to MC5R promotes a biphasic ERK activation, an early and a late phase. ⺠The early peak of pERK is Gi-driven; the sustained is β-arrestins dependent. ⺠A small fraction of pERK1/2 translocates to the nucleus inducing c-Fos expression. ⺠ERK lead to p90RSK and MSK1 phosphorylation in Hela cells and 3T3-L1 adipocytes.
Keywords
PKCMSK1MC5Rp90RSKMitogen- and stress-activated protein kinase 1β-arrestinsMCRsMelanocortin 5 receptorMSHCREBGPCRpKaGFPERKHRPGAPDHERK1/2G-protein coupled receptorG-protein coupled receptor (GPCR)Melanocyte-stimulating hormoneHorseradish peroxidasecAMP-responsive element binding proteingreen fluorescent proteinprotein kinase AProtein kinase Cextracellular-regulated protein kinaseglyceraldehyde-3-phosphate dehydrogenasemelanocortin receptors
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Authors
Adriana R. Rodrigues, Henrique Almeida, Alexandra M. Gouveia,