| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477632 | Molecular and Cellular Endocrinology | 2012 | 8 Pages |
Abstract
⺠In this study, we examined the mechanism of insulin promoted MKP-3 protein degradation in cultured liver cells. ⺠We demonstrated that the MEK/ERK pathway mediates the effect of insulin on degrading MKP-3 protein. ⺠We further confirmed that ERK phosphorylation deficient MKP-3 mutant is resistant to insulin promoted protein degradation. ⺠We also showed that the MEK/ERK pathway affects glucose output, possibly through regulating MKP-3 protein level.
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Authors
Bin Feng, Ping Jiao, Zaiqing Yang, Haiyan Xu,