Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8477637 | Molecular and Cellular Endocrinology | 2012 | 10 Pages |
Abstract
⺠We tested ligand induced vitamin D receptor translocation by novel secosteroids. ⺠We modeled secosteroids bindings to the genomic and non-genomic pockets. ⺠Good correlation between binding to the genomic pocket and translocation exists. ⺠Novel vitamin D hydroxyderivatives inhibit cell proliferation. ⺠Both chain length and the number or positions of hydroxyl groups are important.
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Authors
Tae-Kang Kim, Jin Wang, Zorica Janjetovic, Jianjun Chen, Robert C. Tuckey, Minh N. Nguyen, Edith K.Y. Tang, Duane Miller, Wei Li, Andrzej T. Slominski,