Article ID Journal Published Year Pages File Type
8477637 Molecular and Cellular Endocrinology 2012 10 Pages PDF
Abstract
► We tested ligand induced vitamin D receptor translocation by novel secosteroids. ► We modeled secosteroids bindings to the genomic and non-genomic pockets. ► Good correlation between binding to the genomic pocket and translocation exists. ► Novel vitamin D hydroxyderivatives inhibit cell proliferation. ► Both chain length and the number or positions of hydroxyl groups are important.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
Authors
, , , , , , , , , ,