| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477653 | Molecular and Cellular Endocrinology | 2012 | 13 Pages |
Abstract
⺠Bisphosphonates and statins increase OPG expression. ⺠Bisphosphonates and statins inhibit the expression of CD9, M-CSF, and RANKL. ⺠Bisphosphonates and statins suppressed Ras signallings and activated p38MAPK. ⺠Future studies on the clinical application of this new finding are expected.
Keywords
GGPPMevalonic acid lactoneLIMKCD9M-CSFOPGHMG-CoADEXBMDFPPERK1,25-dihydroxyvitamin D33-hydroxy-3-methylglutaryl-coenzyme ALIM kinaseMAPKMitogen activated protein kinase kinaseOsteoprotegerinStatinsBisphosphonatesBone mineral densityDexamethasoneextracellular signal regulated kinasefarnesyl pyrophosphateMVAmacrophage-colony stimulating factorMEKmitogen activated protein kinasegeranylgeranyl pyrophosphate
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Authors
Masanobu Tsubaki, Takao Satou, Tatsuki Itoh, Motohiro Imano, Masashi Yanae, Chisato Kato, Risa Takagoshi, Makiko Komai, Shozo Nishida,