| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477660 | Molecular and Cellular Endocrinology | 2012 | 11 Pages |
Abstract
⺠Prostate epithelium exists as a hierarchical pathway of cells. ⺠Evidence suggests the cell-of-origin in human prostate cancer is a basal stem cell. ⺠The basal stem cell does not express androgen receptor. ⺠Future cancer therapies must be targeted towards the cancer stem cell population.
Keywords
transgenic adenocarcinoma of the mouse prostatePAPTICp63CRPCPP2AFGFGSTP1LNCaPPSANKX3.1MDRADTABCTMPRSS2TGF-βCSCALDHAMLNOD/SCIDaldehyde dehydrogenaseProstate specific antigenAndrogenTransforming Growth Factor BetaTRAMPDifferentiationSide populationandrogen deprivation therapyProstate cancercastrate resistant prostate cancerProbasinStem cellStem cellsTransit amplifying cellscancer stem cellcytokeratinneuroendocrinebasement membranefibroblast growth factorphosphatase and tensin homologAcute myeloid leukaemiaMultiple drug resistanceProstate intraepithelial neoplasiatransmembrane protease serine 2protein phosphatase 2ProstateProstatic acid phosphatasePINPtenCaPATP-binding cassetteGlutathione S-transferase P1Androgen Receptoroestrogen receptor
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Authors
Emma E. Oldridge, Davide Pellacani, Anne T. Collins, Norman J. Maitland,