| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477686 | Molecular and Cellular Endocrinology | 2012 | 11 Pages |
Abstract
⺠Early-life estrogen/EDC exposures heighten prostate cancer susceptibility with aging. ⺠Prostate stem/progenitor cells express ERs and are targets for estrogenic actions. ⺠Estrogen/EDC modulate prostate stem cell self-renewal and differentiation capabilities. ⺠Estrogenic actions on stem/progenitor cells may increase prostate carcinogenic risk.
Keywords
PSCADHTHSCHGFABCG2BcrpAHRPCDDsPSATCDDPCBs2,3,7,8-Tetrachlorodibenzo-p-dioxinEDCsPOPsPersistent organic pollutantsProstate specific antigenProstate stem cell antigenEndocrine disruptorsEstradiolEstrogenPolychlorinated biphenylsPolychlorinated dibenzo-p-dioxinsDihydrotestosteroneProstate cancerhematopoietic stem cellsHepatocyte growth factorEndocrine Disrupting ChemicalsProstate intraepithelial neoplasiabreast cancer resistance proteinPINaryl hydrocarbon receptorAndrogen ReceptorEstrogen receptorProgesterone receptor
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Authors
Wen-Yang Hu, Guang-Bin Shi, Dan-Ping Hu, Jason L. Nelles, Gail S. Prins,