Article ID Journal Published Year Pages File Type
8477701 Molecular and Cellular Endocrinology 2012 7 Pages PDF
Abstract
► Molecular diversity of cAMP signalling molecules reviewed. ► Detection of cAMP with genetically engineered biosensors has provided a flurry of new information. ► cAMP synthesis may occur at intracellular sites by endocytosed receptor-G protein-adenylyl cyclase complexes. ► Preassembled receptor-G protein-adenylyl cyclase complexes are found intracellularly and may be clinically relevant. ► Hypothetical model of regenerative intracellular cAMP signal propagation is presented.
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