| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477705 | Molecular and Cellular Endocrinology | 2012 | 8 Pages |
Abstract
⺠Coupling between Ca2+ entry through SOC and ER refilling is extremely tight. ⺠SERCA is the third element of SOC and colocalizes with STIM and Orai at puncta. ⺠Coupling is very sensitive to Orai/STIM stoichiometry. ⺠Coupling of SOC to mitochondria is much looser than to the ER.
Keywords
SOCEE–CExtracellular Ca2+ concentrationStore operated Ca2+ entrysarco/endoplasmic reticulum Ca2+ ATPaseOrai1tBH[Ca2+]ERSTIM1CRACYFPCCEThapsigarginGFP[Ca2+]eIP3[Ca2+]c[Ca2+]mexcitation–contractionSOCendoplasmic reticulumPlasma membranecytosolic free Ca2+ concentrationSERCAStromal interaction molecule 1Calcium microdomainsStore-operated calcium entryCapacitative calcium entryyellow fluorescent proteingreen fluorescent proteinStore-operated Ca2+ channel
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Authors
MarÃa Teresa Alonso, Isabel M. Manjarrés, Javier GarcÃa-Sancho,