| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477710 | Molecular and Cellular Endocrinology | 2012 | 7 Pages |
Abstract
⺠TRPM8 is a cold- and menthol-activated Ca2+ permeable non-selective cation channel, expressed in sensory neurons. ⺠TRPM8 is a well established physiological cold sensor. ⺠The activity of TRPM8 depends on the presence of phosphatidylinositol 4,5-bisphosphate (PIP2). ⺠Calcium induced activation of phospholipase C and the ensuing depletion of PIP2 mediates desensitization of TRPM8. ⺠Various other cellular signaling pathways modulate TRPM8 activity.
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Authors
Yevgen Yudin, Tibor Rohacs,