| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477715 | Molecular and Cellular Endocrinology | 2012 | 13 Pages |
Abstract
⺠We describe the organization of the glycerolipid/free fatty acid cycle in the β-cell. ⺠We discuss the significance of β-cell GL/FFA cycle in glucose stimulated insulin secretion. ⺠The role of this cycle in generating signals for β-cell growth is evaluated. ⺠We propose that the lipolytic segment of GL/FFA cycle produces signals for insulin secretion. ⺠We examine the role of the lipogenic segment in generating signals for β-cell growth.
Keywords
ABHD6CPT-IAGPATGSISGPATCGI-58HSLDGATADRPLPAAMPKZDFPKCT2DmaglPPARmonoacylglycerolMAGFFAAMP activated protein kinaseDAGLAtglphosphatidic acidlysophosphatidic acidFree fatty acidInsulin secretionGlucose-stimulated insulin secretiontriglycerideType-2 diabetesdiacylglycerolDAGGlucolipotoxicityendoplasmic reticulumadipose triglyceride lipasehormone sensitive lipaseDAG lipaseLipolysisLipogenesisAdipocyte differentiation-related proteinProtein kinase CZucker Diabetic FattyCarnitine palmitoyltransferase Iglycerol-3-phosphateglycerolipidGlycerophosphate acyltransferase
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Authors
Marc Prentki, S.R. Murthy Madiraju,