| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477723 | Molecular and Cellular Endocrinology | 2012 | 10 Pages |
Abstract
⺠Importance of mitochondria in β-cell metabolism-secretion coupling. ⺠Translation of nutrient stimulation into mitochondrial activation. ⺠Mitochondria derived signals essential for insulin secretion. ⺠Mitochondrial calcium a signal for the amplification of insulin secretion. ⺠Mitochondrial matrix pH controls β-cell energy metabolism.
Keywords
cytosolic isocitrate dehydrogenasePDHAGCSCsGDHTFAMPEPGLP-1Mitochondrial DNASuccinyl-CoA synthetaseβ-CellIsletaspartate–glutamate carriermtDNAmitochondrial transcription factor Aphosphoenolpyruvatelactate dehydrogenaseLDHglucagon-like peptide-1pyruvate dehydrogenasepyruvate carboxylaseCalciumglutamate dehydrogenase
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Authors
Andreas Wiederkehr, Claes B. Wollheim,