| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477756 | Molecular and Cellular Endocrinology | 2011 | 9 Pages |
Abstract
⺠Elevated fatty acid levels have been thought to contribute to insulin resistance. ⺠GLUT4 gene repression may be a mediator for fatty acid-induced insulin resistance. ⺠Glucose/FA metabolism influenced palmitate-induced GLUT4 gene repression (PIGR). ⺠It influenced palmitate-induced impairment of glucose uptake (PIIGU) in C2 myotubes. ⺠Pyruvate depletion plays a critical role in PIGR and PIIGU.
Keywords
BCHTOFAAICARPBSGLUT4CPT-15-aminoimidazole-4-carboxamide-1-β-d-ribofuranosideIKKTCAFFAAMPKPPARαAMP-activated protein kinaseIκB kinasepIgRROSFatty acidFree fatty acidFatty acid oxidationtriacylglycerolGlucose uptakeglucose transporter 4FAOPhosphate buffered salineInsulin resistancePyruvatecarnitine palmitoyl transferase-1Reactive oxygen speciesperoxisome proliferator-activated receptor-alpha
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Authors
Jong Gab Jung, Sung-E Choi, Yoon-Jung Hwang, Sang-A Lee, Eun Kyoung Kim, Min-Seok Lee, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Yup Kang, Kwan-Woo Lee,