| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477764 | Molecular and Cellular Endocrinology | 2011 | 7 Pages |
Abstract
⺠PANDER is a peptide mainly synthesized and secreted by pancreatic β-cells. ⺠PANDER is involved in impairment of β-cell function under pathological conditions. ⺠MCP-1 induces PANDER expression at mRNA and protein levels in β-cells and islets. ⺠MCP-1 upregulates PANDER via Ca2+-ERK1/2-AP-1 and PKC-JNK-AP-1 signaling pathways. ⺠Our findings are helpful for investigating the pathophysiological roles of PANDER.
Keywords
CCL2JnkEGTAMCP-1FAM3BAP-1c-Jun-N-terminal kinasePDX-1PKCMAPKβ-Cellethylene glycol tetraacetic acidPancreatic isletMEKSignal transductionPANDERmonocyte chemotactic protein 1activator protein-1Protein kinase Cmitogen-activated protein kinasemitogen-activated protein kinase kinasechemokine (C–C motif) ligand 2
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Authors
Xinwei Hou, Oumei Wang, Zongmeng Li, Haiwei Mou, Juan Chen, Bo Deng, Lihua Qian, Xiaolong Liu, Yingying Le,