| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477782 | Molecular and Cellular Endocrinology | 2011 | 8 Pages |
Abstract
⺠The pathophysiological link between NAFLD and hepatic insulin resistance is unknown. ⺠We studied the effect of postprandial lipoproteins on hepatic insulin sensitivity. ⺠Postprandial lipoproteins cause liver steatosis and hepatic insulin resistance. ⺠We characterize the underlying molecular mechanisms. ⺠Postprandial lipoproteins are a link between NAFLD and hepatic insulin resistance.
Keywords
PBSNAFLDLDL-receptor-related proteinThlTGRLHSPGLPLGSK-3FCSDAPIHOMA-IRLRPDMEMRAP4′,6-diamidino-2-phenylindoleROSTetrahydrolipstatinhomeostasis model assessment of insulin resistanceLiver steatosisnon-alcoholic fatty liver diseasefetal calf serumInsulin signalingbody mass indexBMIPhosphate buffered salinehepatic lipasePostprandial lipemiaLipoprotein lipasetriglyceride-rich lipoproteinsGlucose metabolismHepatic insulin resistanceReceptor-associated proteinheparan sulfate proteoglycansglycogen synthase kinase 3glycogen synthase Reactive oxygen species
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Authors
Tobias Tatarczyk, Christian Ciardi, Andreas Niederwanger, Michael Kranebitter, Josef R. Patsch, Michael T. Pedrini,