| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8477845 | Molecular and Cellular Endocrinology | 2011 | 8 Pages |
Abstract
⺠AXL and TYRO are components of the TYRO3/AXL/MER (TAM) family of tyrosine kinase receptors. ⺠Axl/Tyro3 null mice were examined for peripheral and central loci of reproductive defects. ⺠Loss of AXL and TYRO3 did not alter folliculogenesis or corpora luteal function and mice had normal pituitary response to GnRH. ⺠Axl/Tyro3 null mice show defective sex steroid-induced LH surge mechanism. ⺠TAM family members play a role in GnRH neuron development and normal female reproductive function.
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Authors
Angela Pierce, Mei Xu, Brian Bliesner, Zhilin Liu, JoAnne Richards, Stuart Tobet, Margaret E. Wierman,