Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8477933 | Molecular and Cellular Endocrinology | 2011 | 11 Pages |
Abstract
Autoimmune adrenocortical failure, or Addison's disease, is a prototypical organ-specific autoimmune disorder. In common with related autoimmune endocrinopathies, Addison's disease is only manageable to a certain extent with replacement therapy being the only treatment option. Unfortunately, the available therapy does not restore the physiological hormone levels and biorhythm. The key to progress in treating and preventing autoimmune Addison's disease lies in improving our understanding of the predisposing factors, the mechanisms responsible for the progression of the disease, and the interactions between adrenal antigens and effector cells and molecules of the immune system. The aim of the present review is to summarize the current knowledge on the role of T cells and cellular immunity in the pathogenesis of autoimmune Addison's disease.
Keywords
ADCCPTPN22APECEDFcγRIP-10MHC class II transactivatorMHC2TAMic-APRRsCTLA4Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophyAutoimmune polyendocrine syndrome type 1adrenalitisCholesterol side chain cleavage enzymeT1DDCsIFN-γNODAdrenal Cortex AutoantibodiesSCCCTLTNFACAAADTCrAPCVNTR21-HydroxylaseCIITATLRsantibody dependent cellular cytotoxicitycytotoxic T lymphocyte antigen 4interferon-γinterleukinAddison's diseaseVariable number of tandem repeatautoimmune regulatorautoimmunityType 1 diabetesNon-obese diabeticDendritic cellsNK cellsNatural killer cellsantigen presenting cellFas LigandFasLtumor necrosis factorAdrenal cortexLymphotoxincytotoxic T lymphocytemajor histocompatibility complexMHCAIREInterferon-inducible protein-10T cell receptorpattern recognition receptorsToll-like receptorsFc gamma receptor
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Authors
Eirik Bratland, Eystein S. Husebye,