Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status

Article ID	Journal	Published Year	Pages	File Type
8477989	Molecular and Cellular Endocrinology	2011	9 Pages	PDF

Abstract

These results indicate that activation of the intrinsic/mitochondrial apoptosis pathway is essential for cytokine-induced beta cell death and the mitochondrial generation of reactive oxygen species, in particular mitochondrial hydrogen peroxide, differentially regulates the Bax/Bcl-2 ratio.

Keywords

CREB second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI XIAP PI-3K GPx1 T1DM APAf-1 IAP IL-1β IFN-γ MAPK NFκB ROS Hydrogen peroxide cycle threshold Smac/DIABLO interferon-γ Interleukin-1β tumor necrosis factor-α Apoptosis Bcl-2 homology domain type 1 diabetes mellitus Pancreatic beta cells Pro-inflammatory cytokines TNF-α nuclear factor kappa B Phosphatidylinositol 3-kinase inhibitor of apoptosis protein H2O2 Bcl-2 proteins X-linked Inhibitor of Apoptosis Protein cAMP response element-binding protein mitogen-activated protein kinase Reactive oxygen species