Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8477989 | Molecular and Cellular Endocrinology | 2011 | 9 Pages |
Abstract
These results indicate that activation of the intrinsic/mitochondrial apoptosis pathway is essential for cytokine-induced beta cell death and the mitochondrial generation of reactive oxygen species, in particular mitochondrial hydrogen peroxide, differentially regulates the Bax/Bcl-2 ratio.
Keywords
CREBsecond mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pIXIAPPI-3KGPx1T1DMAPAf-1IAPIL-1βIFN-γMAPKNFκBROSHydrogen peroxidecycle thresholdSmac/DIABLOinterferon-γInterleukin-1βtumor necrosis factor-αApoptosisBcl-2 homology domaintype 1 diabetes mellitusPancreatic beta cellsPro-inflammatory cytokinesTNF-αnuclear factor kappa BPhosphatidylinositol 3-kinaseinhibitor of apoptosis proteinH2O2Bcl-2 proteinsX-linked Inhibitor of Apoptosis ProteincAMP response element-binding proteinmitogen-activated protein kinaseReactive oxygen species
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Authors
Ilir Mehmeti, Sigurd Lenzen, Stephan Lortz,