Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8478361 | Molecular and Cellular Neuroscience | 2018 | 44 Pages |
Abstract
In this NMDA model, the retina is first affected followed by optic nerve damage. However, we found initiating complement processes in the retina, while more deposits of the terminal complex were present 2â¯weeks after NMDA injection in the optic nerve. The complement system can be activated in waves and possibly a second wave is still on-going in the retina, while the first activation wave is in the final phase in the optic nerve. Only the damaged tissues showed microglia activation as well as proliferation and an increase of complement proteins. Interestingly, the microglia/macrophages (MG/MÏ) in this model were closely connected with the inductors of the classical and lectin pathway, but not with the alternative pathway. However, all three initiating complement pathways were upregulated in the retina. The alternative pathway seems to be triggered by other mechanisms in this NMDA model. Our study showed an ongoing interaction of microglia and complement proteins in a late stage of a degenerative process.
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Authors
Sandra Kuehn, Sabrina Reinehr, Gesa Stute, Cara Rodust, Pia Grotegut, Alexander-Tobias Hensel, H. Burkhard Dick, Stephanie C. Joachim,