Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8478458 | Molecular and Cellular Neuroscience | 2016 | 33 Pages |
Abstract
Our results indicate that deletion of Bdnf in DRG neurons leads to a temporary dysregulation of miR-1, suggesting an impairment of a presumable feedback loop between BDNF protein and its targeting miR-1. This appears to affect its downstream protein Hsp60 and as a consequence might influence the phenotype after inducible Bdnf gene deletion. While this appears to be a MEF2a-/SRF-independent and transient effect, expression levels of various other miRNAs may remain permanently altered.
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Authors
Elena Neumann, Timo Brandenburger, Sonia Santana-Varela, René Deenen, Karl Köhrer, Inge Bauer, Henning Hermanns, John N. Wood, Jing Zhao, Robert Werdehausen,