Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8478483 | Molecular and Cellular Neuroscience | 2016 | 18 Pages |
Abstract
Together, these findings indicate that glia suffers functional early changes in the disease process, changes that may contribute to HD neurodegeneration. Trehalose could be a very promising compound for treatment of HD and other diseases with abnormal protein aggregates. Furthermore our study identifies glial cells as a novel target for trehalose to induce neurotrophic and neuroprotective actions in HD.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Juan Perucho, Ana Gómez, MarÃa Paz Muñoz, Justo GarcÃa de Yébenes, MarÃa Ángeles Mena, MarÃa José Casarejos,