Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8478540 | Molecular and Cellular Neuroscience | 2015 | 14 Pages |
Abstract
These studies demonstrate the utility of the hVGAT-mCherry reporter construct as an effective tool for studying GABAergic neurons differentiated in vitro from human pluripotent stem cells. This approach could provide a means of obtaining large quantities of viable GABAergic neurons derived from disease-specific hiPSCs that could be used for functional assays or high-throughput screening of small molecule libraries.
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Authors
Brooke A. DeRosa, Kinsley C. Belle, Blake J. Thomas, Holly N. Cukier, Margaret A. Pericak-Vance, Jeffery M. Vance, Derek M. Dykxhoorn,