Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8478568 | Molecular and Cellular Neuroscience | 2015 | 10 Pages |
Abstract
We provide complex data on the expression of a variety of factors involved in TRPV1 sensitisation in a CCI model of neuropathic pain. Our study supports evidence for involvement of TRPV1 in the development of neuropathic pain, by showing increased expression of interleukins and kinases responsible for the channel sensitisation. TNFα and NGF seem to play a role in the transition from acute to neuropathic pain, while PKCε in its maintenance. Further studies might confirm their significance as novel targets for the treatment of neuropathic pain.
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Authors
Natalia Malek, Agnieszka Pajak, Natalia Kolosowska, Mateusz Kucharczyk, Katarzyna Starowicz,