Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8478697 | Molecular and Cellular Neuroscience | 2013 | 10 Pages |
Abstract
In developed countries, increased life expectancy is accompanied by an increased prevalence of age-related disorders like cancer and neurodegenerative diseases. Albeit the molecular mechanisms behind the clinically, pathologically and etiologically heterogeneous forms of neurodegeneration are often unclear, impairment of mitochondrial fusion-fission and dynamics emerged in recent years as a feature of neuronal dysfunction and death, pinpointing the need for animal models to investigate the relationship between mitochondrial shape and neurodegeneration. While research on mammalian models is slowed down by the complexity of the organisms and their genomes, the long latency of the symptoms and by the difficulty to generate and analyze large cohorts, the lower metazoan Drosophila melanogaster overcomes these problems, proving to be a suitable model to study neurodegenerative diseases and mitochondria-shaping proteins. Here we will summarize our current knowledge on the link between mitochondrial shape and models of neurodegeneration in the fruitfly. This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'.
Keywords
IAPRRPIFMIOCMFFOMIMpSnPARLMFNFis1Drp1ADOAAPPERGAβUASRGCMn(III)tetrakis(4-Benzoic acid)porphyrin Chlorideopa1ROSoptic atrophy 1autosomal dominant optic atrophyDominant optic atrophyreserve poolelectroretinogramNeurodegenerative diseasesParkinson's diseaseTerminal deoxynucleotidyl transferase dUTP nick end labelingfission 1TUNELtyrosine-hydroxylaseupstream activating sequenceretinal ganglion cellendoplasmic reticulumIndirect flight musclemitochondrial fission factorFusion–fissioninhibitor of apoptosisDrosophila melanogasterMitofusinMitochondriaDopaminergic neuronsOnline Mendelian Inheritance in ManPresenilindynamin-related protein 1amyloid precursor proteinAmyloid plaqueGal4oxygen reactive species
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Authors
Valentina Debattisti, Luca Scorrano,